Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index

• Glavni autori: Kiminori Hori (Autor), Kasumi Ajioka (Autor), Natsuko Goda (Autor), Asako Shindo (Autor), Maki Takagishi (Autor), Takeshi Tenno (Autor), Hidekazu Hiroaki (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Most solid tumors have their own cancer stem cells (CSCs), which are resistant to standard chemo-therapies. Recent reports have described that Wnt pathway plays a key role in self-renewal and tumorigenesis of CSCs. Regarding the Wnt/β-catenin pathway, Dvl (mammalian Disheveled) is an attractive targ...