Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index

• Váldodahkkit: Kiminori Hori (Dahkki), Kasumi Ajioka (Dahkki), Natsuko Goda (Dahkki), Asako Shindo (Dahkki), Maki Takagishi (Dahkki), Takeshi Tenno (Dahkki), Hidekazu Hiroaki (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Most solid tumors have their own cancer stem cells (CSCs), which are resistant to standard chemo-therapies. Recent reports have described that Wnt pathway plays a key role in self-renewal and tumorigenesis of CSCs. Regarding the Wnt/β-catenin pathway, Dvl (mammalian Disheveled) is an attractive targ...