Combining cationic liposomal delivery with MPL-TDM for cysteine protease cocktail vaccination against Leishmania donovani: evidence for antigen synergy and protection.

• 主要な著者: Amrita Das (著者), Nahid Ali (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

BACKGROUND:With the paucity of new drugs and HIV co-infection, vaccination remains an unmet research priority to combat visceral leishmaniasis (VL) requiring strong cellular immunity. Protein vaccination often suffers from low immunogenicity and poor generation of memory T cells for long-lasting pro...