Combining cationic liposomal delivery with MPL-TDM for cysteine protease cocktail vaccination against Leishmania donovani: evidence for antigen synergy and protection.

• Autori principali: Amrita Das (Autore), Nahid Ali (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

BACKGROUND:With the paucity of new drugs and HIV co-infection, vaccination remains an unmet research priority to combat visceral leishmaniasis (VL) requiring strong cellular immunity. Protein vaccination often suffers from low immunogenicity and poor generation of memory T cells for long-lasting pro...