Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension

• Main Authors: Laale F. Alawi (Author), Sanjeev Dhakal (Author), Sana E. Emberesh (Author), Harshal Sawant (Author), Anhar Hosawi (Author), Unmesha Thanekar (Author), Nadja Grobe (Author), Khalid M. Elased (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of the renin angiotensin system plays a pivotal role in the regulation of blood pressure, which is mainly attributed to the formation of angiotensin-II (Ang II). The actions of Ang II are mediated through binding to the Ang-II type 1 receptor (AT1R) which leads to increased blood pressure...