Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation

• Main Authors: Soraia Silva (Author), Joana Bicker (Author), Carla Fonseca (Author), Nuno R. Ferreira (Author), Carla Vitorino (Author), Gilberto Alves (Author), Amílcar Falcão (Author), Ana Fortuna (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depression is a common mental disorder. Its treatment with selective serotonin reuptake inhibitors (SSRIs) is effective only in a fraction of patients, and pharmacoresistance is increasing steadily. Intranasal (IN) drug delivery to the brain stands out as a promising strategy to improve current ther...