Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

Abstract Background Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of hesperetin on the pharmacokinetics of metoprolol i...

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Main Authors: Ravindra Babu Pingili (Author), Sridhar Vemulapalli (Author), Surya Sandeep Mullapudi (Author), Vijaya R. Dirisala (Author), Harsha Sai Chanumolu (Author), Naveen Babu Kilaru (Author)
Format: Book
Published: SpringerOpen, 2023-01-01T00:00:00Z.
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