Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

• Asıl Yazarlar: Ravindra Babu Pingili (Yazar), Sridhar Vemulapalli (Yazar), Surya Sandeep Mullapudi (Yazar), Vijaya R. Dirisala (Yazar), Harsha Sai Chanumolu (Yazar), Naveen Babu Kilaru (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: SpringerOpen, 2023-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Background Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of hesperetin on the pharmacokinetics of metoprolol i...