Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails

• Główni autorzy: Seo-Jung Han (Autor), Jae Eun Jung (Autor), Do Hee Oh (Autor), Minsup Kim (Autor), Jae-Min Kim (Autor), Kyung-Sook Chung (Autor), Hee-Soo Han (Autor), Jeong-Hun Lee (Autor), Kyung-Tae Lee (Autor), Hee Jin Jeong (Autor), In Ho Park (Autor), Eunkyeong Jeon (Autor), Jeon-Soo Shin (Autor), Dongkeun Hwang (Autor), Art E. Cho (Autor), Duck-Hyung Lee (Autor), Taebo Sim (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Identification of highly selective type II kinase inhibitors is described. Two different chiral peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase inhibitor GNF-7 to enhance the selectivity. Kinome-wide selectivity profiling analysis showed that type II kinas...