Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails

• Main Authors: Seo-Jung Han (Author), Jae Eun Jung (Author), Do Hee Oh (Author), Minsup Kim (Author), Jae-Min Kim (Author), Kyung-Sook Chung (Author), Hee-Soo Han (Author), Jeong-Hun Lee (Author), Kyung-Tae Lee (Author), Hee Jin Jeong (Author), In Ho Park (Author), Eunkyeong Jeon (Author), Jeon-Soo Shin (Author), Dongkeun Hwang (Author), Art E. Cho (Author), Duck-Hyung Lee (Author), Taebo Sim (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Identification of highly selective type II kinase inhibitors is described. Two different chiral peptidomimetic scaffolds were introduced on the tail region of non-selective type II kinase inhibitor GNF-7 to enhance the selectivity. Kinome-wide selectivity profiling analysis showed that type II kinas...