Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

• Main Authors: Jerneja Kladnik (Author), Ana Dolinar (Author), Jakob Kljun (Author), David Perea (Author), Judith Grau-Expósito (Author), Meritxell Genescà (Author), Marko Novinec (Author), Maria J. Buzon (Author), Iztok Turel (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zinc pyrithione (1a), together with its analogues 1b-h and ruthenium pyrithione complex 2a, were synthesised and evaluated for the stability in biologically relevant media and anti-SARS-CoV-2 activity. Zinc pyrithione revealed potent in vitro inhibition of cathepsin L (IC50=1.88 ± 0.49 µM) and PLPro...