Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

Zinc pyrithione (1a), together with its analogues 1b-h and ruthenium pyrithione complex 2a, were synthesised and evaluated for the stability in biologically relevant media and anti-SARS-CoV-2 activity. Zinc pyrithione revealed potent in vitro inhibition of cathepsin L (IC50=1.88 ± 0.49 µM) and PLPro...

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Autores principales: Jerneja Kladnik (Autor), Ana Dolinar (Autor), Jakob Kljun (Autor), David Perea (Autor), Judith Grau-Expósito (Autor), Meritxell Genescà (Autor), Marko Novinec (Autor), Maria J. Buzon (Autor), Iztok Turel (Autor)
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Publicado: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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