Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

• Hoofdauteurs: Jerneja Kladnik (Auteur), Ana Dolinar (Auteur), Jakob Kljun (Auteur), David Perea (Auteur), Judith Grau-Expósito (Auteur), Meritxell Genescà (Auteur), Marko Novinec (Auteur), Maria J. Buzon (Auteur), Iztok Turel (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Zinc pyrithione (1a), together with its analogues 1b-h and ruthenium pyrithione complex 2a, were synthesised and evaluated for the stability in biologically relevant media and anti-SARS-CoV-2 activity. Zinc pyrithione revealed potent in vitro inhibition of cathepsin L (IC50=1.88 ± 0.49 µM) and PLPro...