Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome

• Main Authors: Llor Xavier (Author), Carracedo Angel (Author), Castells Antoni (Author), Andreu Montserrat (Author), Bujanda Luis (Author), Ruiz-Ponte Clara (Author), Lazaro Rafael (Author), Ochoa Enrique (Author), Segura Angel (Author), Sanchez-Her (Author), Perez-Carbonell Lucia (Author), Castillejo Maria-Isabel (Author), Egoavil Cecilia (Author), Barbera Victor-Manuel (Author), Martinez-Canto Ana (Author), Guarinos Carla (Author), Castillejo Adela (Author), Clofent Juan (Author), Alenda Cristina (Author), Paya Artemio (Author), Jover Rodrigo (Author), Soto Jose-Luis (Author)
• Format: Book
• Published: BMC, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. R...