Mangiferin Relieves Lipopolysaccharide-Induced Injury by Up-Regulating miR-181a via Targeting PTEN in ATDC5 Cells

• Main Authors: Yunfei Ma (Author), Ying Liu (Author), Yunyan Ma (Author), Nan Jiang (Author), Lei Wang (Author), Bowei Wang (Author), Wanting Niu (Author), Yanjun Hu (Author), Qingrong Lin (Author), Bin Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundMangiferin (MF) was reported to possess anti-inflammatory activity. This investigation tried to probe into the underlying mechanism of MF in osteoarthritis.MethodsATDC5 cells were pretreated with series concentrations of MF (0.1, 1, 5, 10, 15, 20 μM) for 2 h and then were exposed to lipopo...