Knockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism

• Main Authors: Yunkun Liu (Author), Nengwen Huang (Author), Xianghe Qiao (Author), Zhiyu Gu (Author), Yongzhi Wu (Author), Jinjin Li (Author), Chengzhou Wu (Author), Bo Li (Author), Longjiang Li (Author)
• Format: Book
• Published: Nature Publishing Group, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Oral potentially malignant disorders (OPMDs) are precursors of oral squamous cell carcinoma (OSCC). Deregulated cellular energy metabolism is a critical hallmark of cancer cells. Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC1α) plays vital role in mitochondrial e...