Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

• Main Authors: Ahmed Sabt (Author), Omaima M. Abdelhafez (Author), Radwan S. El-Haggar (Author), Hassan M. F. Madkour (Author), Wagdy M. Eldehna (Author), Ezz El-Din A. (Author), Mohamed A. Abdel-Rahman (Author), Laila. A. Rashed (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives bearing different functionalities (4a, b, 8a-d, 11a-d, 13a, b, and 15a-c), and in vitro evaluation of their growth inhibitory activity towards the proliferation of three cancer cell lines; HepG2 (hepatocell...