Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

• Main Authors: Radu Mihaila (Author), Dipali Ruhela (Author), Beverly Galinski (Author), Ananda Card (Author), Mark Cancilla (Author), Timothy Shadel (Author), Jing Kang (Author), Samnang Tep (Author), Jie Wei (Author), R. Matthew Haas (Author), Jeremy Caldwell (Author), W. Michael Flanagan (Author), Nelly Kuklin (Author), Elena Cherkaev (Author), Brandon Ason (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult. Small interfering RNAs (siRNAs) are routinely used to selectively silence a target of interest. Owing to the ease of...