Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

• Автори: Radu Mihaila (Автор), Dipali Ruhela (Автор), Beverly Galinski (Автор), Ananda Card (Автор), Mark Cancilla (Автор), Timothy Shadel (Автор), Jing Kang (Автор), Samnang Tep (Автор), Jie Wei (Автор), R. Matthew Haas (Автор), Jeremy Caldwell (Автор), W. Michael Flanagan (Автор), Nelly Kuklin (Автор), Elena Cherkaev (Автор), Brandon Ason (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2019-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult. Small interfering RNAs (siRNAs) are routinely used to selectively silence a target of interest. Owing to the ease of...