A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

• Autores principales: Jonathon L. Burman (Autor), Leslie S. Itsara (Autor), Ernst-Bernhard Kayser (Autor), Wichit Suthammarak (Autor), Adrienne M. Wang (Autor), Matt Kaeberlein (Autor), Margaret M. Sedensky (Autor), Philip G. Morgan (Autor), Leo J. Pallanck (Autor)
• Formato: Libro
• Publicado: The Company of Biologists, 2014-10-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction results in disease remain unclear. Here, we describe a Droso...