A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

• Main Authors: Jonathon L. Burman (Author), Leslie S. Itsara (Author), Ernst-Bernhard Kayser (Author), Wichit Suthammarak (Author), Adrienne M. Wang (Author), Matt Kaeberlein (Author), Margaret M. Sedensky (Author), Philip G. Morgan (Author), Leo J. Pallanck (Author)
• Format: Book
• Published: The Company of Biologists, 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction results in disease remain unclear. Here, we describe a Droso...