Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

• Egile Nagusiak: Salomé Roux (Egilea), Sara Cherradi (Egilea), Hong Tuan Duong (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Idiosyncratic drug-induced liver injury (iDILI) is a major concern in drug development because its occurrence is unpredictable. Presently, iDILI prediction is a challenge, and cell toxicity is observed only at concentrations that are much higher than the therapeutic doses in preclinical models. Appl...