Cover Image

β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury

Abstract Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules generated by BCAA metabolites. L-β-aminoiso...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ziyue Zhang (Author), Xingbing Li (Author), Jingwen Guo (Author), Bo He (Author), Lianpan Wu (Author), Rongpei Yang (Author), Xingyue Li (Author), Dandong Fang (Author), XiaoLi Yang (Author), Donghai Yang (Author), Fengxian Wang (Author), Ming Tang (Author), Yu Han (Author), Pedro A. Jose (Author), Hongyong Wang (Author), Chunyu Zeng (Author)
Format:	Book
Published:	BMC, 2023-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages
by: Dandong Fang, et al.
Published: (2023)

Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway
by: Yi-Wei Du, et al.
Published: (2023)

Editorial: Design of novel inhibitors for ischemia/reperfusion injury targeting ferroptosis
by: Xuyang Wang, et al.
Published: (2024)

Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα
by: Zhenhua Wu, et al.
Published: (2023)

β-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis
by: Huijuan Wang, et al.
Published: (2017)

Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives
by: Binwei Jin, et al.
Published: (2024)

Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways
by: Xiang Wang, et al.
Published: (2022)

A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents
by: Sofia Moran-Ramos, et al.
Published: (2021)

Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway
by: Shengqiang Li, et al.
Published: (2022)

Corrigendum: Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway
by: Shengqiang Li, et al.
Published: (2022)

AMPK Activation Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating Drp1-Mediated Mitochondrial Dynamics
by: Jingxia Du, et al.
Published: (2022)

Integrated Analysis of Ferroptosis and Immunity-Related Genes Associated with Intestinal Ischemia/Reperfusion Injury
by: Zhu L, et al.
Published: (2022)

Corrigendum: AMPK activation alleviates myocardial ischemia-reperfusion injury by regulating Drp1-mediated mitochondrial dynamics
by: Jingxia Du, et al.
Published: (2024)

Irisin Attenuates Myocardial Ischemia/Reperfusion Injury and Improves Mitochondrial Function Through AMPK Pathway in Diabetic Mice
by: Chao Xin, et al.
Published: (2020)

Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury
by: Haiyan Li, et al.
Published: (2022)

Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling
by: Haoyang Lu, et al.
Published: (2022)

Galangin Attenuates Myocardial Ischemic Reperfusion-Induced Ferroptosis by Targeting Nrf2/Gpx4 Signaling Pathway
by: Yang T, et al.
Published: (2023)

Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis
by: Xie J, et al.
Published: (2022)

Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition
by: Weixiang Chen, et al.
Published: (2023)

Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury
by: Yihang Pan, et al.
Published: (2022)

Cardamonin Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis Through Promoting STAT3 Signaling
by: Yang T, et al.
Published: (2024)

Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathway
by: Chongyang Ma, et al.
Published: (2019)

Ferroptosis-Inducing Nanomedicine for Cancer Therapy
by: Yang Wang, et al.
Published: (2021)

Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury
by: José Lillo-Moya, et al.
Published: (2021)

Inhibition of VDAC1 Rescues Aβ1-42-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β-Catenin Pathways
by: Xinpei Zhou, et al.
Published: (2023)

γ-Glutamylcysteine Exerts Neuroprotection Effects against Cerebral Ischemia/Reperfusion Injury through Inhibiting Lipid Peroxidation and Ferroptosis
by: Ruyi Zhang, et al.
Published: (2022)

Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway
by: Zhangwei Chen, et al.
Published: (2024)

Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway
by: He H, et al.
Published: (2023)

Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
by: Ke Liu, et al.
Published: (2022)

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling
by: Chao Liu, et al.
Published: (2020)

Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway
by: Yang YY, et al.
Published: (2024)

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway
by: Li Wang, et al.
Published: (2022)

Corrigendum: Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
by: Ke Liu, et al.
Published: (2022)

Ammidin ameliorates myocardial hypoxia/reoxygenation injury by inhibiting the ACSL4/AMPK/mTOR-mediated ferroptosis pathway
by: Yue Han, et al.
Published: (2023)

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis
by: Zhenyu Fan, et al.
Published: (2021)

The AMPK-mTOR Pathway Is Inhibited by Chaihu Shugan Powder, Which Relieves Nonalcoholic Steatohepatitis by Suppressing Autophagic Ferroptosis
by: Zheng Liang, et al.
Published: (2024)

RNA-binding protein YBX3 promotes PPARγ-SLC3A2 mediated BCAA metabolism fueling brown adipogenesis and thermogenesis
by: Lin-Yun Chen, et al.
Published: (2024)

Autophagy-dependent ferroptosis is involved in the development of endometriosis
by: Hui Li, et al.
Published: (2023)

Análise de rótulos de BCAA comercializados no município de Volta Redonda-RJ
by: Bruna Guimarães Carvalho, et al.
Published: (2015)

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model
by: Veronika Voronova, et al.
Published: (2022)