A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer's disease

• Main Authors: Sultan Darvesh (Author), Scott Banfield (Author), Maeve Dufour (Author), Katrina L. Forrestall (Author), Hillary Maillet (Author), G. Andrew Reid (Author), Dane Sands (Author), Ian R. Pottie (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer disease (AD). Substrate-based probes have been synthesised to detect ChEs but they have not detected changes in ChE distribution associated with AD pathology. Probes are typically screened using spectrophotometric...