A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer's disease

• Автори: Sultan Darvesh (Автор), Scott Banfield (Автор), Maeve Dufour (Автор), Katrina L. Forrestall (Автор), Hillary Maillet (Автор), G. Andrew Reid (Автор), Dane Sands (Автор), Ian R. Pottie (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Cholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer disease (AD). Substrate-based probes have been synthesised to detect ChEs but they have not detected changes in ChE distribution associated with AD pathology. Probes are typically screened using spectrophotometric...