Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

• Main Authors: Anna B. Osipovich (Author), Frank Y. Zhou (Author), Judy J. Chong (Author), Linh T. Trinh (Author), Mathew A. Cottam (Author), Shristi Shrestha (Author), Jean-Philippe Cartailler (Author), Mark A. Magnuson (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: ASCL1, a pioneer transcription factor, is essential for neural cell differentiation and function. Previous studies have shown that Ascl1 expression is increased in pancreatic β-cells lacking functional KATP channels or after feeding of a high fat diet (HFD) suggesting that it may contribu...