Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei.

• Main Authors: Amy K Dickey (Author), Narisara Chantratita (Author), Sarunporn Tandhavanant (Author), Deirdre Ducken (Author), Lara Lovelace-Macon (Author), Sudeshna Seal (Author), Johanna Robertson (Author), Nicolle D Myers (Author), Sandra Schwarz (Author), Mark M Wurfel (Author), Susanna Kosamo (Author), T Eoin West (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Toll-like receptors (TLRs) are sentinel receptors of the innate immune system. TLR4 detects bacterial lipopolysaccharide (LPS) and TLR5 detects bacterial flagellin. A common human nonsense polymorphism, TLR5:c.1174C>T, results in a non-functional TLR5 protein. Indiv...