Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei.

• Hlavní autoři: Amy K Dickey (Autor), Narisara Chantratita (Autor), Sarunporn Tandhavanant (Autor), Deirdre Ducken (Autor), Lara Lovelace-Macon (Autor), Sudeshna Seal (Autor), Johanna Robertson (Autor), Nicolle D Myers (Autor), Sandra Schwarz (Autor), Mark M Wurfel (Autor), Susanna Kosamo (Autor), T Eoin West (Autor)
• Médium: Kniha
• Vydáno: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

<h4>Background</h4>Toll-like receptors (TLRs) are sentinel receptors of the innate immune system. TLR4 detects bacterial lipopolysaccharide (LPS) and TLR5 detects bacterial flagellin. A common human nonsense polymorphism, TLR5:c.1174C>T, results in a non-functional TLR5 protein. Indiv...