Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation

• Главные авторы: Prakasha Kempaiah (Автор), Karol Dokladny (Автор), Zachary Karim (Автор), Evans Raballah (Автор), John M Ong'echa (Автор), Pope L Moseley (Автор), Douglas J Perkins (Автор)
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• Опубликовано: BMC, 2016-08-01T00:00:00Z.
• Предметы: article
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Abstract Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathways through global gene expression profiling revealed that SMA was characteriz...