LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

• Váldodahkkit: Adrien Flahault (Dahkki), Mathilde Keck (Dahkki), Pierre-Emmanuel G (Dahkki), Lucie Esteoulle (Dahkki), Nadia De Mota (Dahkki), Dominique Bonnet (Dahkki), Catherine Llorens-Cortes (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed LIT01-196, a systemically active metabolically stable apelin-17 analog, p...