Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR-Cas12a system

• Main Authors: Hanseop Kim (Author), Wi-jae Lee (Author), Chan Hyoung Kim (Author), Yeounsun Oh (Author), Lee Wha Gwon (Author), Hyomin Lee (Author), Woojeung Song (Author), Junho K. Hur (Author), Kyung-Seob Lim (Author), Kang Jin Jeong (Author), Ki-Hoan Nam (Author), Young-Suk Won (Author), Kyeong-Ryoon Lee (Author), Youngjeon Lee (Author), Young-Hyun Kim (Author), Jae-Won Huh (Author), Bong-Hyun Jun (Author), Dong-Seok Lee (Author), Seung Hwan Lee (Author)
• Format: Bog
• Udgivet: Elsevier, 2022-06-01T00:00:00Z.
• Fag: article
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The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a system is composed of a Cas12a effector that acts as a DNA-cleaving endonuclease and a crispr RNA (crRNA) that guides the effector to the target DNA. It is considered a key molecule for inducing target-specific gene editin...