ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice
Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects. However, COL4A1 renal disease remains poorly characterized and its pathomolecular mechanisms a...
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Main Authors: | , , , , , , , , , , , |
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Format: | Book |
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The Company of Biologists,
2016-02-01T00:00:00Z.
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A1234.567 |
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