ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

• Главные авторы: Frances E. Jones (Автор), Matthew A. Bailey (Автор), Lydia S. Murray (Автор), Yinhui Lu (Автор), Sarah McNeilly (Автор), Ursula Schlötzer-Schrehardt (Автор), Rachel Lennon (Автор), Yoshikazu Sado (Автор), David G. Brownstein (Автор), John J. Mullins (Автор), Karl E. Kadler (Автор), Tom Van Agtmael (Автор)
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• Опубликовано: The Company of Biologists, 2016-02-01T00:00:00Z.
• Предметы: article
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Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects. However, COL4A1 renal disease remains poorly characterized and its pathomolecular mechanisms a...