State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis

• Main Authors: Evolène Deslignière (Author), Anthony Ehkirch (Author), Bastiaan L. Duivelshof (Author), Hanna Toftevall (Author), Jonathan Sjögren (Author), Davy Guillarme (Author), Valentina D'Atri (Author), Alain Beck (Author), Oscar Hernandez-Alba (Author), Sarah Cianférani (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibody-drug conjugates (ADCs) are biotherapeutics consisting of a tumor-targeting monoclonal antibody (mAb) linked covalently to a cytotoxic drug. Early generation ADCs were predominantly obtained through non-selective conjugation methods based on lysine and cysteine residues, resulting in heterog...