State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis

• Egile Nagusiak: Evolène Deslignière (Egilea), Anthony Ehkirch (Egilea), Bastiaan L. Duivelshof (Egilea), Hanna Toftevall (Egilea), Jonathan Sjögren (Egilea), Davy Guillarme (Egilea), Valentina D'Atri (Egilea), Alain Beck (Egilea), Oscar Hernandez-Alba (Egilea), Sarah Cianférani (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Antibody-drug conjugates (ADCs) are biotherapeutics consisting of a tumor-targeting monoclonal antibody (mAb) linked covalently to a cytotoxic drug. Early generation ADCs were predominantly obtained through non-selective conjugation methods based on lysine and cysteine residues, resulting in heterog...