Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy

• Main Authors: Bo-ang Hu (Author), Yu-lin Li (Author), Hai-tao Han (Author), Bin Lu (Author), Xu Jia (Author), Lu Han (Author), Wei-xuan Ma (Author), Ping Zhu (Author), Zhi-hao Wang (Author), Wei Zhang (Author), Ming Zhong (Author), Lei Zhang (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Fag: article
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Background: The chemotherapeutic doxorubicin (DOX) promotes severe skeletal muscle atrophy, which induces skeletal muscle weakness and fatigue. Soluble guanylate cyclase (sGC) contributes to a variety of pathophysiological processes, but whether it is involved in DOX-induced skeletal muscle atrophy...