Identification of a Novel Bcl-2 Inhibitor by Ligand-Based Screening and Investigation of Its Anti-cancer Effect on Human Breast Cancer Cells

• Glavni autori: Mei Wen (Autor), Zhen-ke Deng (Autor), Shi-long Jiang (Autor), Yi-di Guan (Autor), Hai-zhou Wu (Autor), Xin-luan Wang (Autor), Song-shu Xiao (Autor), Yi Zhang (Autor), Jin-ming Yang (Autor), Dong-sheng Cao (Autor), Yan Cheng (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Bcl-2 family protein is an important factor in regulating apoptosis and is associated with cancer. The anti-apoptotic proteins of Bcl-2 family, such as Bcl-2, are overexpression in numerous tumors, and contribute to cancer formation, development, and therapy resistance. Therefore, Bcl-2 is a promisi...