Identification of a Novel Bcl-2 Inhibitor by Ligand-Based Screening and Investigation of Its Anti-cancer Effect on Human Breast Cancer Cells

• Main Authors: Mei Wen (Author), Zhen-ke Deng (Author), Shi-long Jiang (Author), Yi-di Guan (Author), Hai-zhou Wu (Author), Xin-luan Wang (Author), Song-shu Xiao (Author), Yi Zhang (Author), Jin-ming Yang (Author), Dong-sheng Cao (Author), Yan Cheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bcl-2 family protein is an important factor in regulating apoptosis and is associated with cancer. The anti-apoptotic proteins of Bcl-2 family, such as Bcl-2, are overexpression in numerous tumors, and contribute to cancer formation, development, and therapy resistance. Therefore, Bcl-2 is a promisi...