Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling

• Main Authors: Yumiko Syoji (Author), Ryota Kobayashi (Author), Nako Miyamura (Author), Tsukasa Hirohara (Author), Yoshiko Kubota (Author), Nobuo Uotsu (Author), Kei Yui (Author), Yoshihito Shimazu (Author), Mamoru Takeda (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo conditions whether administration of lutein attenuates the inflammat...