Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib

• Main Authors: Bole Li (Author), Shan Liu (Author), Honglei Feng (Author), Chunshuang Du (Author), Liman Wei (Author), Jie Zhang (Author), Guangwei Jia (Author), Chunnuan Wu (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Backgrounds: Brain metastases occur in approximately 30% of patients with non-small-cell lung cancer (NSCLC). Therefore, the free drug concentration in cerebrospinal fluid (CSF) is strongly associated with the clinical efficacy.Purpose: The present study aimed to develop physiologically based pharma...