Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib
Backgrounds: Brain metastases occur in approximately 30% of patients with non-small-cell lung cancer (NSCLC). Therefore, the free drug concentration in cerebrospinal fluid (CSF) is strongly associated with the clinical efficacy.Purpose: The present study aimed to develop physiologically based pharma...
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Frontiers Media S.A.,
2023-11-01T00:00:00Z.
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A1234.567 |
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| Kopie 1 | Beschikbaar |