Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib

• 主要な著者: Bole Li (著者), Shan Liu (著者), Honglei Feng (著者), Chunshuang Du (著者), Liman Wei (著者), Jie Zhang (著者), Guangwei Jia (著者), Chunnuan Wu (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Backgrounds: Brain metastases occur in approximately 30% of patients with non-small-cell lung cancer (NSCLC). Therefore, the free drug concentration in cerebrospinal fluid (CSF) is strongly associated with the clinical efficacy.Purpose: The present study aimed to develop physiologically based pharma...