Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib

• Váldodahkkit: Bole Li (Dahkki), Shan Liu (Dahkki), Honglei Feng (Dahkki), Chunshuang Du (Dahkki), Liman Wei (Dahkki), Jie Zhang (Dahkki), Guangwei Jia (Dahkki), Chunnuan Wu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Backgrounds: Brain metastases occur in approximately 30% of patients with non-small-cell lung cancer (NSCLC). Therefore, the free drug concentration in cerebrospinal fluid (CSF) is strongly associated with the clinical efficacy.Purpose: The present study aimed to develop physiologically based pharma...