The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice
Background: As the pandemic evolves, post-acute sequelae of CoV-2 (PASC) including cardiovascular manifestations have emerged as a new health threat. This study aims to study whether the Spike protein plus obesity can exacerbate PASC-related cardiomyopathy. Methods: A Spike protein-pseudotyped (Spp)...
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Main Authors: | Xiaoling Cao (Author), Vi Nguyen (Author), Joseph Tsai (Author), Chao Gao (Author), Yan Tian (Author), Yuping Zhang (Author), Wayne Carver (Author), Hippokratis Kiaris (Author), Taixing Cui (Author), Wenbin Tan (Author) |
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Format: | Book |
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Elsevier,
2023-08-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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