Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

• Main Authors: Sagar Narala (Author), Dinesh Nyavanandi (Author), Preethi Mandati (Author), Ahmed Adel Ali Youssef (Author), Abdullah Alzahrani (Author), Praveen Kolimi (Author), Feng Zhang (Author), Michael Repka (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work developed high drug-load pellets for colon targeting in minimal steps by coupling hot-melt extrusion (HME) with a die-surface cutting pelletizer, offering a potential continuous pellet manufacturing process. Ketoprofen (KTP) was selected as a model drug for this study due to its thermal st...