Preparation and in vitro evaluation of hot-melt extruded pectin-based pellets containing ketoprofen for colon targeting

• Главные авторы: Sagar Narala (Автор), Dinesh Nyavanandi (Автор), Preethi Mandati (Автор), Ahmed Adel Ali Youssef (Автор), Abdullah Alzahrani (Автор), Praveen Kolimi (Автор), Feng Zhang (Автор), Michael Repka (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2023-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

This work developed high drug-load pellets for colon targeting in minimal steps by coupling hot-melt extrusion (HME) with a die-surface cutting pelletizer, offering a potential continuous pellet manufacturing process. Ketoprofen (KTP) was selected as a model drug for this study due to its thermal st...