(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

• Asıl Yazarlar: Vildan Betul Yenigun (Yazar), Mario Sirito (Yazar), Alla Amcheslavky (Yazar), Tomek Czernuszewicz (Yazar), Jordi Colonques-Bellmunt (Yazar), Irma García-Alcover (Yazar), Marzena Wojciechowska (Yazar), Clare Bolduc (Yazar), Zhihong Chen (Yazar), Arturo López Castel (Yazar), Ralf Krahe (Yazar), Andreas Bergmann (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2017-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions - (CTG)DM1 in DMPK and (CCTG)DM2 in CNBP. Although transcription of mutant repeats into (CUG)DM1...