Peptide-RNA complexation-induced fluorescence "turn on" displacement assay for the recognition of small ligands targeting HIV-1 RNA

• Main Authors: Liang Qi (Author), Jiayun Zhang (Author), Ying Gao (Author), Pin Gong (Author), Chengyuan Liang (Author), Yao Su (Author), Qiao Zeng (Author), Yafeng Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The regulator of expression of virion (Rev) protein binds specifically to the Rev-responsive element (RRE) RNA in order to regulate the expression of the human immunodeficiency virus (HIV)-1 genes. Fluorescence indicator displacement assays have been used to identify ligands that can inhibit the Rev...