The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000

• Main Authors: Jafar Akbari (Author), Majd Saeedi (Author), Katayoun Morteza-Semnani (Author), Hamid Reza Kelidari (Author), Farshad Sadegh Moghanlou (Author), Gity Zareh (Author), Sohrab Rostamkolaei (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion. Methods: Spironolactone solid dispersions (1:1, 1:2 and 2:1 dru...