High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells

• Główni autorzy: Maria Leticia Castro (Autor), Georgia M. Carson (Autor), Melanie J. McConnell (Autor), Patries M. Herst (Autor)
• Format: Książka
• Wydane: MDPI AG, 2017-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

We have previously shown that exposure to high dose ascorbate causes double stranded breaks (DSBs) and a build-up in S-phase in glioblastoma (GBM) cell lines. Here we investigated whether or not this was due to genotoxic stress as well as metabolic stress generated by exposure to high dose ascorbate...