High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells

• Main Authors: Maria Leticia Castro (Author), Georgia M. Carson (Author), Melanie J. McConnell (Author), Patries M. Herst (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2017-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We have previously shown that exposure to high dose ascorbate causes double stranded breaks (DSBs) and a build-up in S-phase in glioblastoma (GBM) cell lines. Here we investigated whether or not this was due to genotoxic stress as well as metabolic stress generated by exposure to high dose ascorbate...