SH-1028, An Irreversible Third-Generation EGFR TKI, Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer

• Auteurs principaux: Luwei Han (Auteur), Xiaomeng Zhang (Auteur), Zhiqiang Wang (Auteur), Xian Zhang (Auteur), Liwen Zhao (Auteur), Wei Fu (Auteur), Xiaobo Liang (Auteur), Zhibo Zhang (Auteur), Yong Wang (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

SH-1028 is an irreversible third-generation EGFR TKI. Both SH-1028 and osimertinib have a pyrimidine structure (a typical mutant-selective EGFR TKI structure). Compared with osimertinib, SH-1028 is modified on the indole ring, thus resulting in a more stable 6,7,8,9-tetrahydro-pyrrolo [1, 2-a] indol...