SH-1028, An Irreversible Third-Generation EGFR TKI, Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer

• Asıl Yazarlar: Luwei Han (Yazar), Xiaomeng Zhang (Yazar), Zhiqiang Wang (Yazar), Xian Zhang (Yazar), Liwen Zhao (Yazar), Wei Fu (Yazar), Xiaobo Liang (Yazar), Zhibo Zhang (Yazar), Yong Wang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

SH-1028 is an irreversible third-generation EGFR TKI. Both SH-1028 and osimertinib have a pyrimidine structure (a typical mutant-selective EGFR TKI structure). Compared with osimertinib, SH-1028 is modified on the indole ring, thus resulting in a more stable 6,7,8,9-tetrahydro-pyrrolo [1, 2-a] indol...